Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

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A vector gp68hx 12vh-012ca series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC90) in μg/mL.Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good are rhonda allison products medical grade starting point to develop new compounds against tuberculosis.